In the 11th series of this medical drama, many of the doctors' personal relationships are in serious jeopardy. A new face on the team carries an explosive secret that turns Meredith's (Ellen Pompeo) life upside down. While distance between Meredith and Derek (Patrick Demspey) causes marriage friction and a devastating accident seals their fate. Callie (Sara Ramirez) and Arizona (Jessica Capshaw) start to grow apart due to Arizona's work commitments and heartbreaking news plagues April (Sarah Drew) and Jackson's (Jesse Williams) unborn baby.