Dr. Daniel Pierce, a talented but eccentric neuropsychiatrist, is enlisted by the Federal Bureau of Investigation to assist in solving some of its most complex cases in Chicago. Dr. Pierce works closely with Special Agent Kate Moretti, a former student who recruited him to work with the FBI. Also on the team are Max Lewicki, Dr. Pierce's teaching assistant and Natalie Vincent, a hallucination manifested as a result of his schizophrenia who also serves as his best friend.